Abstract:[Objective] To investigate the safety and clinical outcomes of three-point reduction combined with percutaneous kyphoplas- ty (PKP) for thoracolumbar osteoporotic vertebral compression fracture (OVCF) complicated with posterior wall rupture. [Methods] A retro- spective study was done on 95 patients who received surgical treatment for OVCF in our hospital from January 2019 to October 2020. Based on preoperative radiographs, 12 patients were complicated with the posterior wall rupture (the rupture group) , while the remaining 83 pa- tients had no posterior wall rupture (non-rupture group) . All the patients in both groups were treated with three-point reduction, followed by PKP. The data regarding to perioperative period, follow-up and images were compared between the two groups. [Results] All the pa- tients in both groups had operation performed smoothly without serious complications. There were no significant differences between the two groups in terms of reduction time, operation time, fluoroscopy times, volume of bone cement injected, bone cement leakage, postopera- tive walking time and hospital stay (P>0.05) . All of them in both groups were followed up for (15.03±6.77) months on an average, without a significant difference between the two groups in the time to resume full weight-bearing activity (P>0.05) . The VAS and ODI scores signifi- cantly decreased in both groups over time (P<0.05) , whereas which proved not statistically significant between the two groups at any match- ing time points (P>0.05) . Radiographically, the anterior vertebral height significantly increased (P<0.05) , whereas the local kyphotic Cobb angles significantly decreased in both groups postoperatively compared with those preoperatively (P<0.05) . Although the rupture group had significantly lower anterior vertebral height than the non-rupture group preoperatively (P<0.05) , there were no statistically significant dif- ferences in terms of anterior vertebral height and local kyphotic Cobb’s angle between the two groups postoperatively (P>0.05) . [Conclusion] The three-point reduction combined with PKP is safe and effective for treatment of OVCF, especially complicated with posterior wall rupture, which restore the height of the vertebral body and relieve pain.