Abstract:[Objective] To introduce the surgical technique and preliminary clinical results of autogenous grafting of iliac bone block with periosteum for Hepple stage V osteochondral lesions of the talus (OLT) by medial malleolus osteotomy approach. [Methods] From Janu- ary 2018 to December 2019, 26 patients received the abovesaid surgical treatment for Hepple stage V OLT. After three-plane osteotomy of the medial malleolus, involving the horizontal plane, sagittal plane and coronal plane, were conducted by using a mini oscillating saw, the OLT was exposed, and debrided to form a regular bone hole. A bone block with intact periosteum was harvested from the iliac and trimmed to meet the receipt site in shape, and embedded into the bone hole in the recipient area. Finally, the medial malleolus was reduced and fixed with 3 cannulated screws perpendicular to the osteotomy surface respectively. [Results] Twenty-six patients were successfully operated on without serious complications and were followed up for 24 months. At last follow-up, the VAS and AOFAS scores, as well as extension-flexion range of motion of the ankle significantly improved compared with those before operation (P<0.05) . In addition, the CT showed good healing between osteochondral lesion and osteotomy surfaces at the latest follow up. [Conclusion] The three-plane osteotomy technique does effec- tively expose the OLT, while autogenous grafting of iliac bone block with periosteum achieves sound clinical outcomes in mid-term for OLT.