Abstract:[Objective] To explore the biomechanical difference of human tibial fracture under static loading and impact loading. [Methods] Twenty fresh human tibia specimens were randomly divided into two groups, with 10 tibia in each group, 5 of the left side and 5 of the right side. Static axial loading and dynamic impact axial loading were applied respectively to measure the mechanical parameters. [Results] As result of static test, the yield load, yield displacement, ultimate load and ultimate displacement of the left tibia were significant- ly higher than those of the right tibia (P<0.05) . However, in the dynamic impact group, 10 specimens were tested at impact velocity of 2.5 m/s, impact height of 32 cm, and drop weight of 40 kg, and the results showed that there were no significant differences in acceleration, im- pacting extreme load, dynamic deformation and load time pulse width between the left and right tibia specimens in dynamic impact test (P> 0.05) . In term of comparison of two loading state, the dynamic impacting loading had significantly greater ultimate load than the static load- ing (P<0.05) , similarly, the dynamic impacting loading got significantly greater displacement than the static loading (P<0.05) . [Conclusion] Compared with the static axial loading, the dynamic impact loading has significantly greater ultimate load and ultimate displacement of tibia specimens.