Abstract:[Objective] To explore the clinical outcomes of anterior-posterior placement of cannulated lag screw for internal fixation of posterior malleolus fracture fragment in ankle injuries. [Methods] From June 2015 to September 2020, a total of 53 patients, including 24 males and 29 females, received anterior-posterior placement of cannulated lag screw for internal fixation of posterior malleolus fracture frag- ment complicated in ankle injuries in our hospital. The clinical and imaging results were evaluated. [Results] All the patients had operation performed smoothly with operation time of (87.23±9.50) min, and intraoperative blood loss of (105.25±21.60) ml, and then resumed full weight-bearing activity in (2.08±0.78) months on an average postoperatively. As time went during the follow up lasted for a mean of (13.57± 4.08) months, the VAS scores significantly decreased (P<0.05) , while AOFAS scores and ankle dorsal extension- plantar flexion range of motion (ROM) significantly increased (P<0.05) . Radiographically, postoperative images showed satisfactory fracture reduction achieved in all the patients, with significantly declined displacement distance of articular surface compared with that before surgery (P<0.05) . Accord- ing to Burwell-Charnley criteria, 47 patients were marked as anatomic fracture reduction, while the remaining 6 patients as acceptable re- duction. By the time of last follow-up, all patients got fracture union with the joint degeneration of grade 0 in 45 cases, grade 1 in 5 cases, and grade 2 in 3 cases in term of Kellgren-Lawrence classification. [Conclusion] This anterior and posterior placement of cannulated screws does firmly fix the posterior malleolus fracture fragment in ankle injuries, which minimizes the iatrogenic trauma and is beneficial to postoperative recovery.