Abstract:[Objective] To compare the clinical outcomes of open reduction and internal fixation (ORIF) with locking plate fixation ver- sus closed reduction and percutaneous Kirschner wire fixation of Bennett fracture. [Methods] A retrospective study was performed on 52 patients who received surgical treatment for Bennett fracture in our hospital from January 2015 to January 2019. According to preoperative doctor-patient communication, 28 patients had plate used, while the remaining 24 patients had Kirschner wire applied. The data regarding to perioperative period, follow-up and radiographs were compared between the two groups. [Results] All the patients in both groups had cor- responding procedures conducted successfully. The plate group proved significantly superior to the wire group in terms of times of fluorosco- py and the time to return active activity (P<0.05) , whereas the former got significantly more intraoperative blood loss than the latter (P< 0.05) . All the patients were followed up for (18.4±3.6) months on an average, with no a significant difference in the time to resume fullweight bearing activity between the two groups (P>0.05) . The DASH scores decreased significantly in both groups over time after operation (P<0.05) , which were not significantly different between the two groups at 1 year after operation (P>0.05) . Radiographically, fracture align- ment and first metacarpal alignment in both groups significantly improved postoperatively compared with those preoperatively (P<0.05) , which proved not significant between the two groups before operation (P>0.05) , whereas the plate group were significantly better than the wire group at the latest follow-up (P<0.05) . However, there was no significant difference in fracture healing time between the two groups (P>0.05) . [Conclusion] Both plate and wire for fixation are effective treatment of Bennett fracture, with their own advantages and disadvan- tages. By comparison, the ORIF with plate is more accurate and reliable than the percutaneous Kirschner wire.