骨重塑在关节假体松动作用的研究进展

Research progress in the role of bone remodeling on aseptic loosening of prosthesis

摘要:

假体无菌性松动 (aseptic loosening, AL) 是人工关节置换术后主要的临床并发症。目前认为其生物学方面的发病机制主要是人工关节在长期的机械力和生物作用下产生磨损碎片，这些碎片通过诱导巨噬细胞功能的改变调节骨-假体界面免疫环境；此外，磨损颗粒和炎性细胞因子通过刺激成骨细胞、破骨细胞以及它们的前体细胞调节骨重塑的过程，最终导致骨吸收的增加和 AL 的发生。本文针对此问题进行文献综述，为临床医师提供参考。

Abstract:

Aseptic loosening (AL) is the main clinical complication of artificial joint replacement. Currently, it is believed that the main mechanism of the AL is related to the wear debris produced by the prosthetic components with the long-term mechanical and biological ef- fects, which regulate the immune environment of the bone-implant interface by inducing the change of the function of macrophages. In addi- tion, wear debris and inflammatory cytokines regulate the process of bone remodeling by stimulating osteoblasts, osteoclasts, and their pre- cursors, ultimately leading to increased bone resorption and the occurrence of AL. In this paper, literature review is conducted to provide ref- erence for clinicians.