阿司匹林预防关节置换血栓栓塞的研究进展△

Advances in aspirin for the prevention of thromboembolism in joint replacements

摘要:

人工关节置换术后患者由于血管内皮受损等导致静脉血栓栓塞症 (venous thromboembolism, VTE)，具有发病率高、 死亡率高、危害性大的特点，特别是血栓后综合征，严重影响功能和生活质量。目前尚不清楚哪种抗凝剂更合适，多项临床研究表明，阿司匹林可提供有效的 VTE 预防。因此，本文将阐述阿司匹林在髋膝关节置换术方面预防 VTE 的机制以及国内外最新研究进展，为临床预防和治疗提供参考。

Abstract:

Venous thromboembolism (VTE) secondary to major joint arthroplasty is characterized by high morbidity and mortality with high risk, especially post-thrombotic syndrome, which seriously affects patients' function and quality of life due to vascular endothelial dam- age and other factors. Currently it remains unclear which anticoagulant is more appropriate, although several clinical studies have shown that aspirin may provide effective VTE prophylaxis. Therefore, this paper reviewed the mechanism of aspirin for VTE prevention and related re- search progress at home and abroad in hip or knee arthroplasty to provide a reference for clinicians.