Abstract:[Objective] To evaluate the therapeutic outcomes of kinesiology taping (KT) combined with core stability training (CST) for chronic lateral ankle instability (CLAI). [Methods] From October 2014 to December 2020, 50 patients with CLAI were divided into two groups according to random number table method. Of them, 25 patients receive KT and CST on the base of routine exercise (the KT-CST group), while the other 25 patients received the routine exercise only (the routine group). The clinical and test data of the two groups were compared. [Results] The KT-CST group proved significantly superior to the routine group in terms of VAS score [(2.1±1.4) vs (3.0±1.0), P< 0.05] and FADI score [(101.0±18.0) vs (88.0±13.9), P<0.05] after treatment. In addition, the KT -CST group was also significantly better than the routine group in terms of AF/W [(1.1±0.3)Nm/kg vs (0.8±0.5)Nm/kg, P<0.05], AE/W [(0.6±0.2)Nm/kg vs (0.4±0.2)Nm/kg, P<0.05], YBT [(95.2±14.3) vs (88.0±15.7), P<0.05]. [Conclusion] The kinesiology taping combined with core stability training does effectively in- crease the muscle strength around the ankle, thereby increasing ankle stability and function with improved balance capacity for chronic an- kle instability.