Abstract:[Objective] To investigate the clinical results of unilateral percutaneous vertebroplasty (PVP) in the treatment of L5 osteopo- rotic compression fracture (OVCF). [Methods] From November 2018 to July 2022, 47 patients with L5-OVCF were treated with unilateral PVP with puncture skin entry point about 2cm away the outer edge of the L4 pedicle projection, while bone entry point at the outer upper edge of the L5 pedicle. The clinical and imaging data were evaluated. [Results] All the 47 patients were successfully operated on with the operation time of 14~50 min, the injection volume of bone cement of 3.5~10 ml. Bone cement leakage occurred in 11 cases, whereas which not led any complications, such as nerve injury. With time of follow-up lasted for 2 to 26 months (before surgery, at discharge and at last fol- low-up), the VAS score [(7.1±1.0), (1.7±0.8), (0.9±0.6), P<0.001] and ODI scores [(67.6±16.6), (16.9±8.6), (10.2±4.7), P<0.001] signifi- cantly reduced. At the last follow-up, the clinical results were marked as excellent in 19 cases, good in 22 cases, fair in 6 cases, with the ex- cellent and good rate of 87.23% based on the modified MacNab criteria. Radiographically, postoperative radiographs showed that bone ce- ment was distributed across the midline of the vertebral body in all of them. Compared with that preoperatively, the anterior height of verte- bral body significantly increased postoperatively [(2.1±0.4)cm, (2.7 ±0.3)cm, P<0.001]. [Conclusion] This technique of PVP does achieve satisfactory clinical outcomes in short term for L5-OVCF.