Abstract:[Objective] To evaluate the clinical outcomes of manipulation under anesthesia (MUA) combined with isokinetic muscle strength exercise for frozen shoulder. [Methods] A retrospective study was performed on 60 patients who received MUA therapy for frozen shoulder in our hospitals from October 2017 to February 2019. According to doctor-patient communication prior to treatment, 30 patients received isokinetic exercises after treatment of MUA (isokinetic group), while the other 30 patients received routine rehabilitation exercises after treatment of MUA (routine group). The documents regarding to treatment period, follow-up and ISOMED2000 examination were com- pared between the two groups. [Results] All the patients in both groups had treatment finished successfully without serious complications. The isokinetic group had significantly shorter treatment period than the routine group [(84.6±8.3) days vs (103.9±28.3) days, P<0.05], de- spite the fact that former had significantly higher treatment cost than the latter [(2 760.7±134.2) yuan vs (2 355.2±401.9) yuan, P<0.05]. The VAS scores for pain decreased significantly over time in both groups (P<0.05), which in the the isokinetic group was significantly better than that of the routine group 2 and 4 weeks after treatment (P<0.05). In addition, the intensity of analgesic used in the isokinetic group was significantly lower than that in the routine group (P<0.05). All patients were followed up for a mean of (34.5±5.9) months. The ConstantMurley scores, as well as shoulder abduction, flexion, and posterior extension range of motion (ROM) increased significantly over time in both groups (P<0.05). At the last follow-up, the isokinetic group proved significantly superior to the routine group in terms of constant-Mur- ley scores, abductor, flexion, and extension ROMs [(91.4±4.2) vs (88.3±4.6); (165.8±9.6)° vs (149.7±14.8)°; (171.1± 8.3)° vs (159.2±12.6)°; and (49.7±5.6)° vs (40.0±4.7)°, P<0.05]. In terms of the ISOMED2000 test, the peak torque (PT) of 60°/s abduction, 60°/s flexion, 60°/s ex- tension, 120°/s abduction, 120°/s flexion, 120°/s extension, 180°/s abduction, 180°/s flexion, and 180°/s extension significantly increased in both groups at the latest follow-up compared with those before treatment (P<0.05). Although there were no significant differences in the above measures between the two groups before treatment, the isokinetic group was significantly better than the routine group at the latest fol- low-up (P<0.05). [Conclusion] MUA combined with isokinetic exercises does significantly improve the therapeutic effect for frozen shoul- der, which more effectively relieve shoulder pain, increase joint motion and enhance shoulder strength.