Abstract:[Objective] To compare the clinical outcomes of suture bridge fixation with single row anchors combined with bone tunnel (SR-BT) versus double rows of anchors (DR) for humeral greater trochanteric fractures. [Methods] A retrospective study was performed on 44 patients who received surgical treatment for humeral greater trochanteric fractures in our hospital from June 2017 to June 2021. Accord- ing to doctor-patient communication, 24 patients were treated with SR-BT, while the remaining 20 patients were with DR. The periopera- tive period, follow-up and imaging data were compared between the two groups. [Results] All patients in both groups had the operation ac- cordingly performed successfully with no complications such as neurovascular injury. Although there were no significant differences in terms of operation time, intraoperative blood loss, fluoroscopy times, active activity time, incision healing time and hospital stay between the two groups (P>0.05), the SR-BT group had significantly longer incision, whereas significantly lower total hospital expenses than the DR group (P<0.05). Compared with that preoperatively, the VAS score for pain in both groups significantly decreased 7 and 14 days after sur- gery (P<0.05), which was not statistically significant between the two groups at any time points accordingly (P>0.05). All patients were fol- lowed up for (18.1±3.9) months, without a significant difference in the time to return to full weight- bearing activities between the two groups (P>0.05). The ASES score, forward flexion, abduction and external-internal rotation range of motion (ROM) significantly increased in both groups over time (P<0.05), whereas which proved not significantly different between the two groups at any corresponding time points (P<0.05). Radiographically, there were no significant differences in fracture block displacement and acromiohumeral interval (AHI) be- tween the two groups at any time points accordingly (P>0.05). In addition, there was no significant difference in fracture healing time be- tween the two groups (P>0.05). [Conclusion] Both single-row anchors combined with bone tunnel and double-row anchors are effective for internal fixation of humeral greater trochanteric fractures. By contrast, the single-row anchors combined with bone tunnel take benefit of re- ducing medical cost considerably over the double-row anchors.