Abstract:[Objective] To compare the clinical outcomes of transoral (TO) versus transnasal (TN) intratracheal intubations under gener- al anesthesia for short-segment instrumented fusion of Hangman's fractures. [Methods] A retrospective study was performed on 37 patients who received posterior cervical pedicle screw fixation and fusion for Hangman's fractures in our hospital from January 2014 to June 2019. According to the results of preoperative doctor-patient communication, 24 patients underwent TO intubation, while the remaining 13 pa- tients received TN intubation. The perioperative period, follow-up and imaging data of the two groups were compared. [Results] All the 37 patients had operations performed successfully with no complications such as vascular nerve injury during the operation. The TO group proved significantly less laryngeal exposure time and intubation time than the TN group (P<0.05), although there were no significant differ- ences in the success rate of catheterization on the first time, operation time, incision length, intraoperative blood loss, anesthesia- related complications, postoperative ambulation time, incision healing, and hospital stay between the two groups (P>0.05). All of them in both groups were followed up for (16.2±6.7) months on a mean, and there was no significant difference in the time to return to full weight-bear- ing activities between the two groups (P>0.05). The ASIA grade for neurological function, NDI and JOA scores improved significantly in both groups over time (P<0.05), which were not significantly different between the two groups at any time points accordingly (P>0.05). Re- garding image, there was no significant difference in screw placement accuracy between the two groups (P>0.05). The cervical lordotic an- gle and C2~3 slip ratio significantly improved in both groups at the latest follow-up compared with those preoperatively (P<0.05), which were not found significantly different between the two groups at any corresponding time points (P>0.05). [Conclusion] Posterior short-segment instrumented fusion does achieve satisfactory clinical outcomes for the treatment of unstable Hangman's fractures, and both transoral and transnasal intratracheal intubations under general anesthesia are safe and feasible.