椎间盘源性腰痛的发病机制与治疗进展

Research progress on the mechanism and treatment of discogenic low back pain

摘要:

椎间盘退变 （intervertebral disc degeneration, IDD） 是腰痛 （low back pain, LBP） 的主要原因之一，由 IDD 引起的 LBP 被称为椎间盘源性 LBP。导致 IDD 因素众多，本文重点探讨炎症因子调控、神经血管增生在椎间盘源性 LBP 形成过程中的作用，并回顾细胞、生长因子、基因等生物疗法在治疗 IDD 及椎间盘源性 LBP 的进展。

Abstract:

Intervertebral disc degeneration (IDD) is one of the main causes of lower back pain (LBP), while LBP caused by IDD is known as discogenic LBP. There are many factors that lead to IDD, this article focuses on the role of inflammatory factor regulation and neu- rovascular proliferation in the pathogenesis of disc-derived LBP, and reviews advances in cellular, growth factor, and gene biologic thera- pies for the treatment of IDD and discogenic LBP.