Abstract:[Objective] To investigate the surgical treatment and its clinical outcomes for ankle injuries accompanied by complete rup- ture of deltoid ligament (DL). [Methods] From January 2018 to December 2020, a total of 25 patients received surgical treatment for ankle injuries and DL complete fracture. After the fractures were reduced and fixed, and the inferior tibiofibular syndesmosis injury was repaired, the DL was repaired with two suture anchors if significant medial instability was proved. Clinical and imaging documents were evaluated. [Results] All patients were operated on successfully without serious complications, and followed-up time was (19.6±6.8) months on an aver- age. With time elapsed preoperatively, 6 months postoperatively and the latest follow-up, the VAS score for pain decreased significantly [(7.8±0.7), (2.0±0.6), (1.0±0.8), P＜0.05], while the AOSAF score [(53.0±7.2), (83.8±5.7), (93.0±2.9), P＜0.05] and ankle dorsal extensionplantar flexion ROM [(22.3±2.3)°, (44.1±4.8)°, (59.4±2.4)°, P＜0.05] increased significantly, and ankle inversion-eversion ROM significant- ly reduced [(37.9±1.9)°, (27.6±1.2)°, (28.1±1.4)°, P＜0.05]. In terms of imaging, postoperative radiographs showed satisfactory reduction of fractures in all patients with smooth articular surface. The medial clear space (MCS) significantly reduced postoperatively [(5.4±0.6) mm, (3.2±0.3) mm, (3.3±0.4) mm, P＜0.05], and no significant joint degeneration was noted in anyone of them at the latest follow-up. [Conclu- sion] DL repair with two suture anchors does restore ankle joint stability better for ankle injuries with obvious medial instability, which is conducive to early functional exercise and improve clinical consequences.