Abstract:[Objective] To evaluate the clinical significances of early recovery after surgery (ERAS) nursing in surgical treatment of tho- racolumbar fractures. [Methods] From May 2020 to May 2022, a total of 96 patients with thoracolumbar spine fracture admitted to our de- partment were divided into two groups according to random number table method. All patients in both group underwent surgical reduction, decompression and pedicle screw fixation. Of them, 47 patients received ERAS nursing, while other 45 patients received conventional nurs- ing. The perioperative data of the two groups were compared. [Results] All patients in both groups were operated on successfully without se- rious complications. Early postoperative complications were of 6.4% in the ERAS group, while 22.2% in the conventional group, which was statistically significant (P=0.001). The ERAS group proved significantly superior to the conventional group in terms of bowel function recov- ery time [(7.2±1.1) hours vs (10.4±2.3) hours, P<0.001], time of the first fart [(9.5±2.2) hours vs (16.4±2.6) hours, P<0.001], time of the first defecation [(25.6±4.9) hours vs (43.2±5.6) hours, P<0.001], postoperative ambulation time [(3.1±0.6) days vs (5.3±1.1) days, P<0.001] and hospital stay [(8.4±1.0) days vs (12.0±1.3) days, P<0.001]. The VAS score for pain and general comfort questionnaire (GCQ) score were sig- nificantly improved in both groups over time (P<0.05), which were not statistically significant between the two groups before operation (P> 0.05), whereas in the ERAS group were significantly better than those in the conventional group 1 to 7 days postoperatively (P<0.05). [Con- clusion] ERAS nursing used in the perioperative period for thoracolumbar fractures does promote the recovery of intestinal function, re- lieve postoperative pain and improve comfort of the patients.