Abstract: [Objective] To compare the clinical efficacy of fixation with laminar hook versus pedicale screw for treatment of simple bilat- eral lumbar spondylolysis in children and adolescent. [Methods] A retrospective study was performed on 43 patients who received surgical treatment for simple bilateral spondylolysis in our department from January 2016 to January 2019. According to doctor-patient communica- tion, 20 patients underwent internal fixation with laminar hooks (LH), while the other 23 patients underwent fixation with pedicle screw (PS). The perioperative, follow-up and imaging data were compared between the two groups. [Results] All patients in both groups were successful- ly operated on. The LH group proved significantly superior to the PS group in terms of operation time [(79.9±7.8) min vs (103.9±8.6) min, P< 0.05], incision length [(6.2±0.9) cm vs (7.8±0.8) cm, P<0.05] and intraoperative blood loss [(120.8±16.2) ml vs (177.0±12.8) ml, P<0.05]. However, there was no statistical significance in the number of intraoperative fluoroscopy, postoperative walking time, incision healing scale and hospital stay between the two groups (P>0.05). Patients in both groups were followed up for more than 24 months, and there was no statis- tical significance in the time to resume full weight-bearing activities between the two groups (P>0.05). As time went on, the VAS and ODI scores significantly decreased in both groups (P<0.05). The LH group was significantly better than the PS group in terms of VAS score [(2.0± 0.7) vs (2.4±0.5), P<0.05], ODI score [(30.2±6.0) vs (38.7±2.5), P<0.05] 3 months postoperatively, whereas which became not statistically sig- nificant at the latest follow-up (P>0.05). Regarding to imaging, the isthmus was completely healed within 6 months postoperatively in all pa- tients of both groups. There were no statistically significant differences in intervertebral height and lumbar lordosis angle between the two groups at any corresponding time points (P>0.05). [Conclusion] The laminar hook used for fixation of simple lumbar spondylolysis in chil- dren takes advantages of decreasing iatrogenic trauma and improving clinical outcomes over the pedicle screw fixation.