Abstract:[Objective] To evaluate the clinical outcomes of endoscopic decompression combined with internal treatment of traditional Chinese medicine (TCM) for lumbar spinal stenosis. [Methods] A retrospective study was conducted on 45 patients who received endoscopic surgery for lumbar spinal stenosis in our hospital from January 2021 to December 2021. According to the results of preoperative doctor-pa- tient communication, 22 patients were treated with endoscopic decompression combined with traditional Chinese medicine (combination group), while the other 23 patients were treated with endoscopic decompression alone (simple group). The perioperative, follow-up and imag- ing data were compared between the two groups. [Results] The operation was successfully completed in both groups, without significant differ- ences in operation time, incision length, intraoperative fluoroscopy times, intraoperative blood loss, time to resume ambulation postoperative- ly, incision healing grade and hospital stay between the two groups (P>0.05). At the latest follow-up lasted for more than 12 months the TCM symptom scores, VAS for lumbago and leg pain scores, as well as ODI score in both groups significantly improved compared with those before surgery (P<0.05). Although there were no statistically significant differences in the above parameters between the two groups before surgery (P>0.05), the combination group proved significantly superior to the simple group in terms of TCM symptom score [(6.2±2.4) vs (11.5± 4.2), P< 0.05], low back pain VAS [(0.9±0.7) vs (1.8±1.4), P<0.05] and leg pain VAS [(0.9± 0.7) vs (1.0±0.9), P<0.05] and ODI score [(4.3±3.15) vs (6.9±4.2), P<0.05] at last follow-up. Radiographically, there were no significant changes in intervertebral height or lumbar lordotic angle be- tween the two groups at the last follow-up compared to the preoperative period (P<0.05), whereas the spinal canal area was significantly en- larged in both groups (P<0.05). At any corresponding time points, there was no significant difference in the above image indexes between the two groups (P>0.05). [Conclusion] This endoscopic decompression combined with internal treatment of traditional Chinese medicine does re- lieve nerve compression and dredge the blockage of supervision vessel, significantly improve nerve function, and promote rapid recovery.