Abstract:[Objective] To evaluate the effect of targeted nursing during the perioperative period of lumbar decompression and fusion on postoperative abdominal distension and constipation. [Methods] From January 2022 to January 2023, 120 patients who were undergoing lumbar decompression and fusion for lumbar degenerative diseases in our hospital were included in this study, and were divided into the tar- geted group and conventional group by random number table method, with 60 cases in each group. The postoperative abdominal distension and constipation, anxiety and satisfaction with nursing work were compared between the two groups. [Results] All patients in both groups were successfully operated on without serious perioperative complications. The targeted group proved significantly superior to the convention- al group in terms of abdominal distension incidence (25.0% vs 58.3%, P=0.003), abdominal distension score [(0.5±0.3) vs (1.3±0.4), P= 0.001], constipation incidence (35.0% vs 63.3%, P=0.014), constipation score [(0.6±0.2) vs (1.4±0.9), P=0.002], anxiety score [(50.7±2.3) vs (57.7±7.6), P=0.002] and nursing satisfaction score [(9.0±1.0) vs (8.1±1.6), P=0.006]. [Conclusion] The targeted nursing does effectively reduce the occurrence of postoperative abdominal distension and constipation, relieve patients' anxiety status, improve patient satisfaction.