Abstract:[Objective] To compare the clinical outcomes of two tenodesis techniques for ruptured long head of biceps tendons (LHBT) in arthroscopic repairing rotator cuff repair. [Methods] A retrospective study was performed on 72 patients who underwent arthroscopic treatment for rotator cuff tear complicated with LHBT rupture in our hospital from January 2015 to March 2020. After arthroscopic repairing rotator cuff tear, 37 patients had the LHBT fixed by interference screw (IS), while the remaining 35 patients had LHBT fixed by suture an- chor (SA). The perioperative, follow-up and imaging data of the two groups were compared. [Results] All patients in both group had opera- tion performed smoothly without serious complications. The IS group proved significantly superior to the SA group in terms of operative time [(61.4±2.5) min vs (70.2±2.6) min, P<0.001]. As time went during the follow-up lasted for (16.4±1.5) months, the VAS scores decreased sig- nificantly (P<0.05), while the ASES score increased significantly in both groups (P<0.05). At the latest follow-up, the IS group proved sig- nificantly superior to the SA group in ASES score [(13.3±0.2) vs (12.1±0.2), P<0.001], despite of the fact that there was no significant differ- ence in VAS score between the two groups (P>0.05), and there was no significant difference in the time to resume full weight-bearing activi- ty between the two groups (P>0.05). Radiographically, the coracohumeral distance (CHD) increased significantly (P<0.05), whereas the cor- acoid overlap (CO) decreased significantly in both groups over time (P<0.05). There were no significant differences in CHD and CO be- tween the two groups at corresponding time points (P>0.05). [Conclusion] Compared with suture anchor, the interference screw used for te- nodesis of ruptured LHBT does shorten the operation time, reduce postoperative drainage, and is conducive to functional recovery for rota- tor cuff tear complicated with LHBT rupture.