Abstract:[Objective] To analyze the correlation between the hospital cost structure and the total cost in insured orthopedic patients to provide a theoretical basis for reasonably controlling the hospital cost of orthopedic patients, ensuring the safety of medical insurance fund and restricting the unreasonable growth of medical cost. [Methods] A total of 7 773 orthopedic patients in a hospital from 2019 to 2022 were included into this study. According to the classification of the cost structure, the total hospitalization cost of orthopedic patients was divided into 6 categories. The gray correlation analysis was conducted for the 6 evaluation items, and the correlation between the six evaluation items and the average cost was studied by taking the average cost of per time as the "reference value". [Results] From 2019 to 2022, the average hospitalization cost of insured orthopedic patients showed a trend of increase first and then decrease, but the overall trend was increasing, and the proportion of increase was the largest in 2020. The trend of the proportion of drugs was the same as the average cost of hospitaliza- tion, but the proportion of consumables was on the contrary, showing an upward trend. In term of grey correlation analysis, medical expenses had the highest correlation before the diagnosis classification-based payment. After the new medical insurance payment, the consumables cost had the highest correlation, followed by medical and administrative costs. [Conclusion] The focus of medical insurance supervision on hospital expenses of orthopedic patients should be on the high-value consumables, followed by rational drug use and reasonable charges. At the same time, we should pay attention to the value of orthopedic nursing staff and improve the enthusiasm of medical staff in diagnosis and treatment. At the hospital level, we should pay attention to and gradually explore and promote the reform of diagnosis intervention packet pay- ment methods, and improve the level of hospital fine management.