Abstract:[Objective] To compare the efficacy of SuperPath approach versus posterolateral approach (PLA) with a small incision for to- tal hip arthroplasty (THA) in the treatment of osteonecrosis of the femoral head (ONFH). [Methods] A total of 65 patients who were admitted to our hospital from June 2017 to June 2019 for end-stage ONFH were divided into two groups by random number method. All the patients in both groups received THA, including 35 patients with SuperPath approach, while the other 30 patients with PLA approach. The periopera- tive, follow- up and radiographic documents were compared between the two groups. [Results] The surgical procedures were successfully completed in both groups without neurovascular injury and other serious complications. Although the SuperPath group consumed significant- ly longer operation time than the PLA group (P<0.05), the former was significantly superior to the latter in terms of total incision length, time to return walking postoperatively and hospital stay (P<0.05). The follow-up period lasted for more than 24 months. The SuperPath group re- sumed full weight- bearing activity significantly earlier than the PLA group (P<0.05). The VAS score significantly decreased (P<0.05), whereas Harris score significantly increased in both groups over time (P<0.05). The SuperPath group proved significantly superior to the PLA group in abovesaid scores at 6 months after surgery (P<0.05), nevertheless, the differences became not statistically significant between the two groups at the latest follow-up (P>0.05). Regarding to imaging evaluation, there were no significant changes in acetabular abduction and acetabular anteversion (P>0.05), whereas the discrepancy in limb length significantly decreased at the latest follow-up compared with those preoperatively in both groups (P<0.05). At corresponding time points, there was no statistical significance in the above radiographic items between the two groups (P>0.05). [Conclusion] The SuperPath approach has an advantage of minimized iatrogenic trauma over the PLA, which is beneficial to early postoperative recovery.