质子感知受体在骨代谢中的研究进展

Research progress in proton sensing receptors on bone metabolism

摘要:

卵巢癌G 蛋白偶联受体1（ovarian cancer G protein-coupled receptor 1, OGR1） 亚家族广泛分布于人体组织中，该受体具有质子敏感特性，可以通过受体组氨酸残基感知细胞外pH 值变化，对人体细胞功能进行调节。质子感知受体不仅与肿瘤的发生、免疫系统、神经系统及血管系统等密切相关，还能调节成骨细胞骨形成和破骨细胞骨吸收来影响骨代谢。当骨形成和骨吸收动态平衡被打破以后，会导致骨量异常以及相关骨病的发生。本文就质子感知受体在骨代谢中的作用进行综述。

Abstract:

Ovarian cancer G protein-coupled receptor 1 (OGR1) subfamily was widely distributed in human tissues, which has protonsensitiveproperties and can sense changes in extracellular pH through the receptor of histidine residues, thereby regulating the functions ofvarious human cells. Proton-sensing receptors not only closely related to tumorigenesis, immune system, nervous system, and vascular sys-tem, but also to regulate osteoblast bone formation and osteoclast bone resorption affecting bone metabolism by the changes of extracellularpH value. As the bone metabolic balance is disrupted, it leads to abnormal bone mass and related bone disease. This article reviews the re-search progress on the role of proton-sensitive ovarian cancer G protein-coupled receptor 1 in bone metabolism.