Abstract:[Objective] To evaluate the clinical efficacy of cannulated screws and retrograde intramedullary nail for femoral neck frac-ture accompanied with femoral shaft fractures. [Methods] A retrospective study was conducted on 22 patients who received cannulatedscrews for femoral neck fractur and retrograde femoral intramedullary nail for the same-side femoral shaft fractures in our hospital from Jan-uary 2017 to January 2020. The clinical and imaging data were evaluated. [Results] All patients were successfully operated on, with no neu-rovascular injury and other serious complications, and followed up for (28.4±8.5) months. Compared to those 3 months after surgery, theHarris scores [(54.4±2.1), (77.8±3.1), P＜0.05], HSS score [(80.4±2.4), (94.8±2.4), P＜0.05], hip internal- external rotation range of motion(ROM) [(50.4±2.1)°, (74.6±1.9)°, P＜0.05], hip flexion-extension ROM [(60.7±4.8)°, (90.23±2.9)°, P＜0.05], the knee flexion-extensionROM [(100.3±2.5) °, (120.8±2.1) °, P＜0.05] significantly increased at the latest follow-up. Radiographically, all patients got femoral neckfracture and femoral shaft fractures reduced well after surgery. The healing time of femoral neck fractures was of (6.1±2.0) months, while thefemoral shaft fractures was of (6.8±2.2) months. There was no significant change in Tonnis hip osteoarthritis grade at the last follow-up com-pared with that 3 months after surgery (P＞0.05). [Conclusion] The cannulated screws and retrograde intramedullary nail for femoral neckfracture accompanied with femoral shaft fractures have good flexibility in operation, do achieve satisfactory clinical results.