Abstract:[Objective] To investigate the effect of transcutaneous electrical acupoint stimulation (TEAS) on the early response after to-tal knee arthroplasty (TKA). [Methods] From May 2022 to June 2023, a total of 91 patients who were undergoing TKA for knee osteoarthri-tis were divided into two groups according to the random number table method. Of them, 46 cases in the TEAS group received TEAS treat-ment on the basis of conventional treatment, while other 45 patients in the routine group received the conventional treatment only. The clini-cal and blood test indexes of the two groups were compared. [Results] There were no significant differences in operation time, total bloodloss and incidence of adverse events between the two groups (P＞0.05). The TEAS group proved significantly superior to the routine group interm of dynamic pain VAS score at 7 days [(4.5±1.4) vs (5.1±1.3), P=0.018] and 14 days [(2.4±1.1) vs (3.9±1.5), P＜0.001], static pain VASscore at 7 days [(2.0±1.1) vs (2.6±1.5), P=0.043] and 14 days after surgery [(1.0±0.9) vs (1.4±1.1), P=0.033]. The TEAS group was also sig-nificantly better than the routine group regarding suprapatellar 10 cm circumference [(45.3±2.9) cm vs (48.1±4.3) cm, P=0.038] and theknee ROM [(122.3±9.3)° vs (115.6±7.4)°, P＜0.001] 14 days postoperatively. With respect of blood test, the TEAS group was also significant-ly superior to the routine group in Fib [(3.8±0.9) s vs (4.3±1.0) s, P=0.027], D-D [(7.1±15.8) mg/L vs (14.7±23.1) mg/L, P=0.048] and PT[(11.5±0.6) s vs (11.2±0.6) s, P=0.026] 7 days postoperatively. [Conclusion] TEAS might effectively reduce the early reaction after TKAand promote postoperative recovery.