Abstract:[Objective] To present the surgical technique and preliminary clinical results of percutaneous drug-loaded calcium sulfateand pedicle screw fixation for lumbar brucellosis. [Methods] A total of 19 patients received abovementioned surgical treatment for lumbarbrulellosis from July 2017 to July 2021. After percutaneous pedicle screws were placed on the contralateral side, a MAST Quadrant channelsystem was installed on the affected side to expose the facet and the infected intervertebral space. The lesion was completely debrided, andthen the drug-loaded calcium sulfate particles were prepared and implanted through the channel into the affected intervertebral space,which finally covered with a gelatin sponge immersed with rifomycin. The pedicle screws were placed on the same side, and the screw-rodsystem was adjusted and fasten. After the operation, rehabilitation function exercise was conducted under protection with a brace. [Results]All the 19 patients were successfully operated on without serious complications, and followed up for (18.3±8.7) months in a mean. At the lat-est follow-up, all the patients got bony fusion of the affected space without infection recurrence and implant failure, associated with signifi-cant decrease of ESR, CRP and VAS score (P＜0.05), whereas significant improvement in term of ASIA neurological function grade. [Con-clusion] On the basis of standardized antimicrobial therapy, percutaneous drug-loaded calcium sulfate and pedicle screw fixation are mini-mally invasive treatment, with continuous and slow release of antimicrobial drugs, which is conducive to infection control and has definiteclinical efficacy for lumbar brucella spondylitis.