Abstract:[Objective] To evaluate the early clinical results of percutaneous cannulated screw and bone cement osteoplasty for periace-tabular metastases. [Methods] A retrospective study was performed on 36 patients who received surgical treatment for periacetabular metas-tases in our hospital from May 2020 to June 2022. According to doctor-patient communication, 16 patients were treated with percutaneousscrew combined with bone cement osteoplasty (the combined group), while the remaining 20 patients were treated with simple percutaneousbone cement osteoplasty (the simple group). Clinical and imaging data were compared between the two groups. [Results] Although the com-bined group was significantly greater than the simple group in terms of operation time [(70.4±7.4) min vs (39.8±7.2) min, P<0.05], fluorosco-py times [(23.1±5.7) times vs (13.3±5.1) times, P<0.05], there was no significant difference in terms of the amount of bone cement injectedand postoperative ambulation time (P>0.05). With time of the follow-up lasted for (10.4±2.5) months on a mean, the VAS, Harris and SF-36scores significantly improved in both groups (P<0.05), which was not statistically significant between the two groups before surgery (P>0.05).However, the combined group was significantly superior to the simple group in terms of VAS score 1 week postoperatively [(2.4± 0.6) vs (3.3 ±1.2), P<0.05], 3 months postoperatively [(2.1±1.2) vs (3.2±1.6), P<0.05], despite of the fact that there was no significant difference in Harrisscore and SF-36 score between the two groups (P>0.05). Regarding imaging, the pathological fracture and lesion size remained unchangedin both groups postoperatively compared with those the preoperatively (P>0.05), which were not of significant differences between the twogroups at any time points accordingly (P>0.05). [Conclusion] Percutaneous hollow screw combined with bone cement in the treatment ofperiacetabular metastases can effectively relieve pain, improve hip function and improve patients' quality of life.