Abstract:[Objective] To compare the clinical efficacy of percutaneous screw-rod system versus plate in the treatment of unstable pel-vic ring fractures. [Methods] A retrospective study was conducted on 57 patients who underwent open reduction and internal fixation (OR-IF) for Tile type C pelvic fractures in our department from January 2016 to December 2020. After the ORIF for the posterior ring had beenperformed, 30 patients had the anterior ring fixed with screw-rod system, while the other 27 patients were with plate. The perioperative, fol-low-up and imaging documents were compared between the two groups. [Results] All the patients in both groups were operated on success-fully without nerve and vascular injury and other serious complications. The screw-rod group proved significantly superior to the plategroup in terms of operation time [(59.1±12.2) min vs (77.2±18.3) min, P<0.05], total incision length [(15.4±3.2) cm vs (27.5±4.3) cm, P<0.05] and intraoperative blood loss [(75.2±15.3) ml vs (350.4±50.6) ml, P<0.05], nevertheless there were no significant differences in thenumber of intraoperative fluoroscopy, incision healing grade and hospitalf stay between the two groups (P>0.05). The early complicationswere 3.3% (1/30) in the screw-rod group, whereas 18.5% (5/27) in the plate group, which was not statistically significant (P=0.091). All pa-tients were followed up for more than 12 months, and the screw-rod group resumed full weight-bearing activity significantly earlier than theplate group [(92.6±11.2) days vs (107.4±12.1) days, P<0.05]. The VAS scores for pain decreased significantly (P<0.05), while the Majeedscore increased significantly over time in both groups (P<0.05). The screw-rod group was significantly better than the plate group in term ofMajeed score at 3 months [(77.5±5.6) vs (71.8±3.6), P<0.05] and 6 months [(88.7±3.6) vs (82.5±1.6), P<0.05]. Radiographically, there wereno significant differences in reduction quality according to Matta's criteria and internal fixation position between the two groups at any timepoints accordingly (P>0.05). However, the screw-rod group got fracture healing on images significantly earlier than that of plate group (P<0.05). [Conclusion] The percutaneous screw-rod system used for the anterior ring fixation in Tile type C pelvic fractures has advantages ofshortening operation time, minimizing surgical trauma, reducing bleeding, enhancing fracture healing of the pelvis over the traditional platefixation.