Abstract:[Objective] To compare the clinical efficacy of modified Nice knots and loop plate (MNLP) versus hook plate (HP) for fixa-tion of acromioclavicular dislocation. [Methods] A retrospective study was done on 34 patients who received surgical treatment for Rock-wood type III or V acromioclavicular dislocation in our hospitals from January 2017 to January 2020. According to preoperative doctor-pa-tient communication, 18 patients underwent open reduction and fixation with MNLP, while the remaining 16 patients were with HP. Theperioperative period, follow-up and imaging data of the two groups were compared. [Results] All patients in both groups had correspondingsurgical procedures performed without nerve, vascular injury and other complications, without significant differences in terms of operationtime, intraoperative blood loss, hospital stay, incision length, incision healing grade between the two groups (P>0.05), and followed up for(16.4±3.6) months on a mean. Compared with those preoperatively, the pain VAS, Constant and ASES scores in both groups were signifi-cantly improved 9 months after operation (P<0.05). There was no significant difference in abovementioned items between the two groups be-fore operation (P>0.05), the MNLP group proved significantly superior to the HP group in terms of VAS score [(1.1±0.8) vs (2.5±1.2), P<0.001], Constant score [(87.1±2.7) vs (75.7±2.8), P<0.001] and ASES scores [(83.8±3.7) vs (77.8±5.2), P<0.001] 9 months postoperatively.Regarding to imaging, the acromioclavicular distance (ACD) and coracoclavicular distance (CCD) in both groups decreased significantly atthe last follow-up compared with those preoperatively (P<0.05), whereas which were not significantly different between the two groups atany time points accordingly (P>0.05). [Conclusion] The modified Nice knots and loop plate do achieve considerably better clinical conse-quences over the hook plate fixation for acute acromioclavicular dislocation.