Abstract:[Objective] To explore the clinical outcomes of posterior lumbar interbody fusion (PLIF) with bone cement augmented pedi-cle screw by graduated or non-graduated pushrods for osteoporotic lumbar degenerative diseases. [Methods] A retrospective study was per-formed on 42 patients who underwent PLIF with bone cement augmented pedicle screw for osteoporotic lumbar degenerative diseases fromOctober 2021 to October 2022. According to doctor-patient communication, 22 patients had the graduated pushrod used for bone cementaugmentation of the pedicle screws, while the other 20 patients had the ungraduated rod used. The perioperative, follow-up and imaging dataof the two groups were compared. [Results] The graduated group proved significantly superior to the ungraduated group in terms of operationtime [(142.7±53.4) min vs (164.3±58.6) min, P<0.05], intraoperative fluoroscopy times [(10.2±2.3) times vs (15.3±1.8) times, P<0.05], intra-operative blood loss [(246.6±123.8) ml vs (324.1±113.8) ml, P<0.05], despite of insignificant differences in total incision length, incisionhealing grade, walking time and hospital stay between the two groups (P>0.05). In addition, the graduated group got significantly lower bonecement leakage rate than the ungraduated group (4.5% vs 11.3%, P<0.05). The follow-up period lasted for (13.9±3.2) months in a mean, andthere was no significant difference in time to resume full weight-bearing activities between the two groups (P>0.05). The VASs and ODIscores decreased significantly over time in both groups (P<0.05), which were not statistically significant between the two groups at any timepoints accordingly (P>0.05). Regarding imaging, the lumbar lordosis (LL) significantly improved in both groups 3 months after surgery and atthe last follow-up compared with those preoperatively (P<0.05). However, there were no significant differences in terms of LL angle andBridwell fusion grade between the two groups at any time points accordingly (P>0.05). [Conclusion] In the case of lumbar interbody fusionfor osteoporotic lumbar degenerative diseases, the bone cement augmented pedicle screw with the graduated pushrod does reduce the num-ber of fluoroscopy, shorten the operation time and reduce the risk of leakage of bone cement.