Abstract:[Objective] To compare the clinical efficacy of vesselplasty (VP) with or without manual reduction for osteoporotic verte- bral compression fracture (OVCF). [Methods] A retrospective study was done on 65 patients who underwent VP for OVCF in our hospital from July 2020 to April 2022. According to doctor-patient communication, 31 patients had manual reduction conducted, followed by the VP (the reduction group), while the other 34 patients underwent VP without manual reduction before surgery (the non- reduction group). The documents regarding to perioperative period, follow-up and images were compared between the two groups. [Results] All patients were successfully operated on without serious complications. The reduction group proved significantly superior to the non- reduction group in terms of operation time [(31.4±6.7) min vs (38.9±13.0) min, P=0.006] and the bone cement leakage rate (22.6% vs 58.8%, P=0.003), al- though there were no significant differences in intraoperative fluoroscopy times, bone cement injection amount, postoperative ambulation time, hospital stay and hospitalization cost between the two groups (P>0.05). All patients were followed up for more than 1 year, and there was no significant difference in the time to resume full weight-bearing activities between the two groups (P>0.05). The VAS and ODI scores decreased significantly over time in both groups (P<0.05), whereas which were not statistically significant between the two groups at any time points accordingly (P>0.05). With regard of imaging, the local kyphotic Cobb angle and anterior vertebral height were significantly im- proved in both groups at the latest follow-up compared with those preoperatively (P<0.05), however, there were no statistically significant differences in the local kyphotic Cobb angle and anterior vertebral height between the two groups at any corresponding time points (P> 0.05). [Conclusion] The VP combined with manual reduction does better reduce the chance of bone cement leakage, and shorten the opera- tive time in the treatment of osteoporotic vertebral compression fractures.