Abstract:[Objective] To investigate the clinical efficacy of tibial tuberosity osteotomy combined with double-tunnel isometric reconstruction of medial patellofemoral ligament (MPFL) in the treatment of recurrent patellar dislocation. [Methods] A retrospective study was conducted on 20 patients who received surgical treatment for recurrent patellar dislocation in our hospital from May 2017 to May 2022. All of them underwent double-tunnel isometric reconstruction MPFL combined with tibial tuberosity osteotomy. The clinical and imaging data were evaluated. [Results] All the patients had operation performed successfully with operation time of (65.3±6.7) min, and were followed up for (12.2±0.7) months. Compared with those before operation, the Lysholm score [(53.7±9.9), (86.5±6.0), P<0.001], Kujala score [(55.5±6.3), (83.7±7.9), P<0.001] and IKDC scores [(54.6±8.7), (86.7±6.9), P<0.001] were significantly increased 12 months postoperatively. No further dislocation occurred in anyone of them utill the last follow-up. Radiographically, the patellofemoral congruence angle (PCA) [(28.2±4.4)°, (13.3±2.6)°, P<0.001], patella title angle (PTA) [(23.1±4.8)°, (8.9±2.9)°, P<0.001], tibial tubercle-trochlear groove distance (TT-TG) [(22.1± 1.74) mm, (11.9±1.9) mm, P<0.001] and quadricep angle (Q Angle) [(23.1±2.4)°, (15.1±2.6)°, P<0.001] decreased significantly 12 months after operation compared with those preoperatively, but the patellofemoral cartilage thickness remained unchanged (P>0.05). [Conclusion] The tibial tuberosity osteotomy combined with double-tunnel isometric reconstruction of MPFL is an effective treatment for recurrent patellar dislocation.