Abstract:[Objective] To compare the clinical efficacy of "stretching soft tissue and distracting bone” reduction combined with per-cutaneous pedicle screw fixation (PSF) versus PSF only for single-segment thoracolumbar fracture. [Methods] A retrospective study wasdone on 47 patients who received surgical treatment for type A single-segment thoracolumbar fracture without neurological symptoms inour hospital from January 2019 to June 2021. According to the preoperative doctor-patient discussion, 24 patients received "stretching softtissue and distracting bone” reduction combined with PSF (the reduction group), while other 23 patients had PSF performed only (the con-ventional group). The documents regarding perioperative period, follow-up and images were compared between the two groups. [Results] Al-though there were no significant differences in total incision length, intraoperative blood loss, success rate of one-time screw placement,postoperative walking time, grade of incision healing, hospital stay and incidence of early complications between the two groups (P>0.05),the reduction group was significantly greater than the conventional group in terms of operation time [(74.0±4.6) min vs (58.8±7.4) min, P<0.001] and intraoperative fluoroscopy times [(32.3±2.8) times vs (26.1±3.2) times, P<0.001]. All the patients in both group were followed upfor a mean of (15.2±2.5) months. The VAS and ODI scores in both groups were significantly improved over time after surgery (P<0.05), andthe reduction group proved significantly better than the conventional group in term of ODI scores at the last follow-up [(1.4±0.9) vs (3.1±1.6), P<0.001]. Radiographically, the local kyphotic angle (LKA), vertebral wedge angle (VWA) and anterior vertebral height (AVH) weresignificantly improved in both group after surgery (P<0.05). By comparison, the reduction group was significantly superior to the convention-al group in terms of LKA [(2.3±2.1) ° vs (6.2±3.6) °, P<0.001], VWA [(2.8±0.7) ° vs (6.7±2.0) °, P<0.001] and AVH [(94.1±2.5) % vs (85.7±4.9) %, P<0.001] at the latest follow-up. [Conclusion] This "stretching soft tissue and distracting bone” reduction combined with percuta-neous pedicle screw fixation (PSF) does restore the height of the injured vertebra better to correct the wedge-shaped vertebral deformity,avoid the occurrence of kyphosis, and maintain the long-term clinical effect for single-segment thoracolumbar fracture.