骨H型血管生成机制及影响因素的研究现状△

Current research of the mechanism and influencing factors of Type H vessels formation in bone

摘要:

骨血管在骨生长、重塑和损伤修复中发挥重要作用，H 型血管是一类同时高表达CD31 与Emcn 的骨血管亚型，具有显著的解剖特征与年龄依赖性减少特点，深度参与血管生成与骨形成之间的偶联。一些细胞因子如缺氧诱导因子1α、血管内皮生长因子A、血小板衍生生长因子BB、神经轴突导向因子3 等可参与调控H 型血管的生成，同时药物治疗、物理治疗和转移性肿瘤也能对H 型血管产生影响。本文通过回顾近年文献，总结H 型血管生成的分子机制与影响因素，以期为骨折不愈合、骨代谢异常等骨病的治疗提供新思考。

Abstract:

Blood vessels in bone tissue play an important role in bone growth, development, remodeling and injury repair. Type H ves-sels are a subtype of bone vessels with high expression of CD31 and Emcn, which have significant anatomical characteristics and age-de-pendent decline characteristics, and are deeply involved in the coupling between angiogenesis and bone formation. Some cellular mole-cules, such as hypoxia inducible factor-1, vascular endothelial growth factor-A, platelet derived growth factor-BB, and slit guidance ligand3, are involved in regulating the formation of Type H vessels. Meanwhile, drugs therapy, physical therapy, and metastatic tumors can also af-fect Type H vessels. In this paper, the molecular mechanism and influencing factors of Type H vessels formation are reviewed based on theliteratures in recent years, to provide a new idea for the diagnosis and treatment of bone diseases such as fracture nonunion and abnormalbone metabolism.