Abstract:[Objective] To introduce the surgical technique and clinical outcomes of F3 mini locking plate for ankle fractures com-bined with posteromedial fragment. [Methods] From February 2019 to February 2021, 12 patients underwent surgical treatment for anklefractures complicated with posteromedial fragment in our hospital with time interval from injury to surgery from 1 to 10 days. Surgical expo-sure was adopted among anterior and posterior window between tibialis posterior and neurovascular bundle through posteromedial ap-proach. Following reduction, fixation of fractures was conducted, including screw or tension band fixation of the anterior collicular fragment,posteromedial and posterior collicular fragment, and F3 mini locking plate for overall fixation. [Results] There was no intraoperative neuro-vascular injury, no incision infection and flap necrosis in anyone of them. No posterior tibialis tendon irritation and implant failure, loss offracture reduction as well as joint incongruity were observed in anyone at the last follow-up. The AOFAS ankle-hind foot score was from 86to 96 at the latest follow-up. [Conclusion] The fixation of posteromedial fragment with F3 mini-locking plate can achieve effective stabili-ty, reduce implant-related complications, and facilitate the recovery of ankle function, which is a feasible surgical scheme.