Abstract:[Objective] To investigate the clinical outcomes of osteochondral autografting through medial malleolus "V" shaped osteotomy approach for osteochondral lesions of the talus (OLT). [Methods] A retrospective study was conducted on 24 patients who received osteochondral autografting through medial malleolus "V" shaped osteotomy approach for OLT from January 2018 to June 2020. The clinical and imaging documents were evaluated. [Results] All the patients were successfully operated on without nerve or vascular injury, with average operation time of (71.4±12.0) min, and intraoperative blood loss of (39.2±11.2) ml, and were followed up for (24.2±6.6) months. Compared with those preoperatively, the VAS score for pain [(6.1±0.7), (1.0±0.9), (0.9±0.6), P<0.001], AOFAS ankle and hindfoot scores [(66.8±4.8), (89.5±5.4), (93.0±5.1), P<0.001] significantly improved, while knee Lysholm scores were not significantly changed at 1 year after surgery and the latest follow-up (P>0.05). In term of imaging, the magnetic resonance observation of cartilage repair tissue (MOCART) score [(43.3± 7.0), (66.5±7.1), (69.2±6.5), P<0.001] significantly increased, and all patients got osteotomy healed and OLT lesions repaired well, with the Takaku ankle degeneration grade unchanged significantly (P>0.05). [Conclusion] The osteochondral autografting through medial malleolus "V" shaped osteotomy approach is safe and reliable in the treatment of osteochondral lesions of the talus.