退变椎间盘神经长入的研究进展

Research progress in nerve ingrowth in intervertebral disc degeneration

摘要:

椎间盘退变（intervertebral disc degeneration, IVDD） 是下腰痛（low back pain, LBP） 的主要原因。IVDD 过程伴随着细胞外基质代谢异常、促炎细胞因子释放增加和神经纤维及血管长入。同时已有研究表明，IVDD 组织神经长入主要包括感觉神经和交感神经，神经在内层纤维环（annulus fibrosus, AF） 和髓核（nucleus pulposus, NP） 组织内的异位长入是LBP 的主要原因。本文对IVDD 组织内神经长入的进展进行概述，对神经纤维的调控和神经递质的作用进行讨论，希望通过针对神经长入的研究，有助于确定新的治疗方向。

Abstract:

Intervertebral disc degeneration (IVDD) is the leading cause of low back pain (LBP), which is accompanied by abnormal me-tabolism of extracellular matrix, increased release of proinflammatory cytokines, and ingrowth of nerve fibers and blood vessels. At the sametime, it has been shown that the innervation of IVDD tissue mainly includes sensory nerves and sympathetic nerves, and the ectopic in-growth of the nerve into the inner annulus fibrosus (AF) and nucleus pulposus (NP) is the main cause of LBP. Here we give an overview ofthe progress of nerve ingrowth in IVDD, discuss the regulation of nerve fibers and the role of neurotransmitters. The research on nerve in-growth may help to identify new therapeutic directions.