Abstract:[Objective] To evaluate the reliability and effectiveness of combined high tibial osteotomy (HTO) and distal femoral osteotomy (DFO) in the correction of complex knee varus in adolescents. [Methods] From July 2015 to June 2022, 10 patients (12 knees) underwent combined DFO and HTO osteotomy. The clinical and imaging documents were evaluated. [Results] All the patients had operation performed successfully without complications, such as vascular and nerve injury during the operation. All the 10 patients were followed up with an average of (21.9±10.3) months, with walking time of (36.9±18.2) days. Compared with those preoperatively, the HSS score [(86.6±5.1), (97.2±1.2), P<0.001] and Lysholm score [(77.5±15.3), (95.7±2.7), P<0.001] significantly increased, whereas VAS scores [(4.2±1.2), (0.7± 0.3), P<0.001] significantly decreased at the last follow-up. As for imaging, the proximal medial tibial angle (MPTA) [(72.3±6.6)°, (85.2± 1.9)° , P<0.001], mechanical lateral distal femoral angle (mLDFA) [(78.2 ± 5.3)° , (87.4 ± 0.9)° , P<0.001], and femorotibial angle (FTA) [(182.8±4.4)°, (176.6±2.1)°, P<0.001] significantly improved, additionally, the leg length discrepancy (LLD) [(24.6±6.8) mm, (11.9±4.3) mm, P<0.001], and the mechanical axis deviation [(30.9±11.3) mm, (10.4±3.8) mm, P<0.001] significantly declined. [Conclusion] Combined DFO and HTO osteotomy do effectively correct the varus deformity of the knee, and increase the length of the affected limb, achieve satisfactory short-term consequence.