Abstract:[Objective] To investigate the value of enhanced recovery after surgery (ERAS) protocol used in the perioperative period of pedicle screw fixation of thoracolumbar fractures. [Methods] From April 2019 to June 2023, 80 patients who received pedicle screw fixation of thoracolumbar fractures were included in this study and randomly divided into two groups by coin tossing. Of them, 40 patients received ERAS care, while the other 40 received conventional care. The documents regarding perioperative period and postoperative pain were compared between them. [Results] All patients in both groups had fracture fixed with pedicle screw successfully without serious complications. There was no significant difference in operation time and intraoperative blood loss between the two groups (P<0.05), however, the ERAS group was significantly superior to the conventional groups in terms of the exhaust time [(19.4±5.6) hours vs (24.2±6.7) hours, P< 0.001], bed rest time [(22.5±6.2) hours vs (27.1±7.8) hours, P=0.005], hospital stay [(6.6±2.0) days vs (7.8±2.5) days, P=0.020], and the total incidence of complications (5.0% vs 22.5%, P=0.023). Regarding pain, the ERAS group was marked significantly lower VAS scores 2 hours, 1 day and 3 days postoperatively than the conventional group (P<0.05), whereas which became not significantly different between the two groups 5 days after surgery (P>0.05). In addition, the ERAS group was also significantly better than the conventional group in terms of time of first analgesia given [(7.4±2.8) hours vs (10.6±3.3) hours, P<0.001] and the number of PCA compressed [(4.6±1.4) times vs (6.0±1.8) times, P<0.001]. [Conclusion] ERAS care in the perioperative period of pedicle screw fixation of thoracolumbar fractures can promote early recovery and reduce early postoperative pain.