Abstract:[Objective] To investigate the clinical outcomes of cluster nursing in preventing laryngeal irritation after anterior cervicalsurgery. [Methods] A retrospective study was conducted on 172 patients who underwent anterior cervical surgery in our hospital. Of them,83 patients who were admitted from July 2022 to November 2022 received routine nursing, while other 89 patients admitted from December2022 to April 2023 received cluster nursing. The Bazaz dysphagia grade, swallowing quality of life (SWAL-QOL) and general comfort ques-tionnaire (GCQ) were compared between the two groups. [Results] All patients in both groups were successfully operated on without seriouscomplications. The cluster group proved significantly superior to the routine group 2 days and 5 days after surgery in terms of Bazaz dyspha-gia grade [none/mild/medium/severe, (49/23/12/5) vs (41/18/14/10), P=0.004; (80/7/2/0) vs (50/18/10/5), P=0.015], SWALQOL score[(56.1±7.9) vs (50.6±10.0), P=0.014; (60.1±5.9) vs (52.3±9.8), P=0.001], and GCQ score [(93.3±7.1) vs (89.3±10.4), P=0.003; (96.1±3.4) vs(93.5±7.5), P=0.002]. In addition, the former was also significantly better than the latter in term of incidence of throat irritation [case (%), 6(6.7) vs 17 (20.0), P=0.001]. [Conclusion] The intervention of cluster nursing after anterior cervical surgery is beneficial to prevent throat ir-ritation and improve patients' experience to medical service.