Abstract:[Objective] To introduce the surgical technique and preliminary clinical results for the management of soft tissue complica-tions of in bone transportation for tibial bone defect secondary to osteomyelitis. [Methods] From January 2017 to December 2022, 54 pa-tients with chronic osteomyelitis of tibia were treated with bone transportation, with the soft tissue complication treated accordingly. The lo-cal debridement, skin grafting or skin flap transplantation, and skin stretch device were used for skin infection or necrosis around the junc-tion. Local soft tissue release was used for occlusal soft tissue incarceration, while bone grafting at the joint ends combined with replacementof plate external fixation was conducted for soft tissue incarceration at the joint end complicated with bone nonunion. In addition, local de-bridement and skin stretching were performed for late soft tissue defect with bone exposed again. [Results] The bone lengthened ranged from3 cm to 14 cm, and the external fixation index was of 1.2~2.5 months /cm in the 54 patients. Of them, 30 patients got conjunctional end heal-ing without soft tissue complications, whereas the remaining 24 patients had soft tissue related complications around the conjunctional ends,accounting for 44.4%. However, all the local soft tissue complications were solved effectively after the corresponding treatment as mentionedabove. [Conclusion] The incidence of soft tissue complications of bone transportation with Ilizarov frame for tibial bone defect secondary os-teomyelitis is high, including soft tissue reinfection in the early stage, simple soft tissue incarceration, soft tissue incarceration with bone non-union, and late soft tissue redefect with bone exposure. Although the related complications can eventually be solved through later treatment,the obvious prolongation of the treatment process and increase the burden of patients should be paid great attention to by orthopedic surgeon.