Abstract:[Objective] To compare the short-term clinical outcomes of fixed-bearing unicompartmental knee arthroplasty (FB-UKA)verus mobile bearing unicompartmental knee arthroplasty (MB-UKA) for medial knee osteoarthritis. [Methods] A retrospective study wasconducted on 98 patients who received UKA for medial knee osteoarthritis from January 2020 to February 2023. According to the results ofdoctor-patient communication, 43 underwent FB-UKA with Zimmer prosthesis, while other 55 patients were treated with MB-UKA by usingOxford prosthesis. The data of perioperative period, follow-up and images were compared between the two groups. [Results] All patients inboth groups had UKA performed successfully without statistically significant differences in operation time, incision length, intraoperativeblood loss, ambulation time, incision healing grade, hospital stay and hospital cost between the two groups (P>0.05). All of them in bothgroups were followed up for (12.7±4.8) months in an average, and there was no significant difference in the time to regain full weight-bearingactivities between the two groups (P>0.05). The VAS and WOMAC scores significantly decreased (P<0.05), while HSS score, forgotten jointscore (FJS) and knee extension-flexion ROM significantly increased in both groups at the latest follow-up compared with those preoperative-ly (P<0.05). At the last follow-up, the MB group was significantly better than the FB group in terms of FJS [(85.5±3.5) vs (84.1±2.7), P=0.032], and knee extension-flexion ROM [(125.4±3.5)° vs (123.7±4.2)°, P=0.031]. As for imaging, HKAA and JICA were significantly im-proved in both groups after surgery (P<0.05), while TPVA remained unchanged significantly (P>0.05). At corresponding time points, therewere no significant differences in the above imaging items between the two groups (P>0.05). [Conclusion] For medial knee osteoarthritis,the MB-UKA has better forgotten joint score regarding to short-term clinical consequence over the FB-UKA.