Abstract:[Objective] To explore the clinical outcomes of preformed elastic intramedullary nail (ESIN) fixation for distal radius diaph-yseal metaphyseal junction fracture (DRDMJ) in children. [Methods] A retrospective analysis was conducted on 80 children who receivedsurgical treatment for DRDMJ in our hospital from January 2020 to September 2022. According to doctor-patient communication, 40 casesunderwent retrograde ESIN preformed accoding to 3D CT reconstruction (the preformed group), while other 40 cases underwent convention-al retrograde ESIN fixation (the non-preformed group). The documents regarding perioperative period, follow-up, and images were com-pared between two groups. [Results] There was no statistically significant difference in surgical time, incision length, intraoperative fluoros-copy frequency, intraoperative bleeding, incision healing grade, active activity time, and hospitalization time between the two groups (P>0.05). All children in both groups were followed up for (15.0 ± 3.5) months in a mean, and there was no statistically significant difference intime to resume full weight-bearing activity between the two groups (P>0.05). The MEPS score and Cooney wrist score significantly in-creased in both groups (P<0.05) over time, which proved not statistically significant between the two groups at any time points accordingly(P>0.05). The preformed group had significantly lower incidence of postoperative fracture displacement during follow-up than the non-pre-formed group [4/40 (10.0%) vs 11/40 (27.5%), P=0.045]. As for imaging, compared with those before surgery, the palmar tilt (PT), radial in-clination (RI), and radial length (RL) in both groups significantly increased 4 weeks postoperatively and at the last follow-up (P<0.05). At 4weeks after surgery and the last follow-up, the preformed group proved significantly superior to the non-preformed group in terms of PT[(8.9±2.4)° vs (7.6±2.1)°, P=0.012; (11.3±2.0)° vs (10.4±1.8)°, P=0.038] and RL [(7.6±2.1) mm vs (6.5±2.0) mm, P=0.019; (9.6±1.7) mm vs(8.8±1.8) mm, P=0.044]. [Conclusion] The preformed retrograde ESIN fixation for pediatric DRDMJ does improve postoperative fracture re-duction, and is of great significance in reducing the incidence of secondary fracture displacement.