蛋白质组学在脊柱相关疾病研究的现状△

Current status of proteomics in the research of related spine diseases

摘要:

目前蛋白质组学技术大致可分为双向电泳技术、生物质谱技术、液质联用技术等，其具备快速筛选及鉴定疾病的特异性生物标记物的优点，可以从蛋白质水平角度对机体内各种生理变化、病理转变过程进行全面的认识。目前蛋白质组学技术在医学领域得到广泛应用。本文就其在脊柱相关疾病中的应用现状进行综述，包括椎间盘退变（intervertebral disc degeneration,IDD）、脊髓损伤（spinal cord injury, SCI） 发生与修复机制研究以及脊柱韧带骨化与肥厚、颈椎病（cervical spondylosis, CS）、强直性脊柱炎（ankylosing spondylitis, AS）、脊柱侧弯、脊柱结核（spinal tuberculosis, STB）、神经管缺陷（neural tube defects,NTDs） 生物标记物筛选和发生机制研究等。

Abstract:

With rise and rapid development of proteomics technology, this technology provides an overall and comprehensive under-standing of various physiological and pathological changes in the body from the perspective of protein level due to its advantages of rapidscreening and identification of specific biomarkers of diseases. At present, proteomics technology has been widely used in the medical field.This article reviews the current status of its application in related spinal diseases, including intervertebral disc degeneration (IDD), spinalcord injury focused on the pathogenesis and repair mechanism, as well as spinal ligament ossification and hypertrophy, cervical spondylosis(CS), ankylosing spondylitis (AS), scoliosis, spinal tuberculosis (STB), neural tube defects (NTDs) biomarker screening and pathogenesis re-search.