毛囊多能干细胞修复脊髓损伤的研究进展△

Reseach advance in hair follicle-associated-pluripotent stem cells for spinal cord injury

摘要:

脊髓损伤（spinal cord injury, SCI） 会导致运动和感觉功能障碍。因高致残率、高致死率的疾病特点，给患者及社会带来了巨大的经济负担。毛囊多功能干细胞（hair follicle- associated- pluripotent stem cells, HAPSCs） 来源于毛囊隆突处，其具有多向分化潜能并表达胚胎神经嵴干细胞特异性标志物，是作为SCI 细胞移植治疗的新兴潜力细胞。既往研究已证明移植该细胞可使脊髓损伤造模动物的运动及感觉功能明显恢复。细胞、药物及组织工程与其联合应用可加强其治疗效果。本文就近年来HAPSCs 在脊髓损伤的研究进展进行综述，旨在阐明该细胞的研究现状并预测其未来的研究方向。

Abstract:

Spinal cord injury (SCI) cause motor and sensory dysfunction. Due to high disability and fatality, it brings huge economicburden to patients and society. Hair follicle-associated pluripotent stem cells (HAPSCs) originated from hair follicle prominences had multi-ple potential for differentiation and expressed specific markers of embryonic neural crest stem cells. It is a new potential cell for SCI celltransplantation therapy. Previous studies have shown that the transplantation of these cells can significantly restore the motor and sensoryfunctions of spinal cord injury in animal models. The combination of cell, drug and tissue engineering can enhance its therapeutic effect. Inthis paper, we reviewed the progress of HAPSCs research in spinal cord injury in recent years, aiming to clarify the current research statusand future research direction of HAPSCs.