Abstract:[Objective] To evaluate the short-term efficacy of total hip arthroplasty (THA) through direct anterior approach in lateraldecubitus position. [Methods] A total of 50 patients received THA in our hospital from October 2022 to September 2023. Based on preoper-ative patient communication, 25 patients had THA performed through the direct anterior approach (DAA) in lateral decubitus position,while other 25 patients were through the traditional posterolateral approach (PLA). Short-term clinical and imaging data were compared be-tween the two groups. [Results] All patients in both groups were successfully operated on without serious complications. The DAA groupproved significantly superior to the PLA group in terms of operation time [(48.5±2.2) min vs (63.9±3.9) min, P<0.001], incision length [(7.8±3.1) cm vs (10.4±3.2) cm, P=0.005], intraoperative blood loss [(222.0±39.8) ml vs (292.3±53.6) ml, P<0.001], ambulation time [(2.1±0.5)days vs (3.5±0.9) days, P<0.001], and hospitalization [(5.1±1.0) days vs (8.1±1.7) days, P<0.001]. All the patients were followed up for morethan 6 months. Compared with those at discharge, the VAS scores and Harris scores significantly improved in both groups at the last followup(P<0.05). At the last follow-up, the DAA group was significantly better than the PLA group regarding VAS score [(1.6±1.1) vs (2.5±1.5),P=0.033] and Harris score [(81.2±11.6) vs (72.5±9.9), P=0.007]. Postoperative images showed that the prosthetic position was good in allpatients of both groups, and there were no significant differences in acetabular anterior inclination and abduction angle between the twogroups (P>0.05). [Conclusion] Compared with the traditional posterolateral approach, the direct anterior approach in lateral decubitus posi-tion does reduce surgical trauma, and is more beneficial to early recovery.