Abstract:[Objective] To investigate the clinical results of two kinds of internal fixation of femoral supracondylar osteotomy for kneeflexion deformity secondary to poliomyelitis. [Methods] A retrospective analysis was performed on 60 patients who received femoral supra-condylar osteotomy for knee flexion deformity due to sequelae of poliomyelitis in our hospital from January 2018 to June 2021. According todoctor-patient communication, 30 cases had osteotomy site fixed by dynamic condyle screw (DCS group), 30 cases were fixed by lockingplate (LP group). The perioperative, follow-up and imaging data were compared between the two groups. [Results] All patients in bothgroups had operation performed successfully. The DCS group proved significantly superior to the LP group in terms of operative time [(54.1±4.3) mim vs (62.5±3.2) min, P<0.001], total incision length [(13.4±1.0) cm vs (14.6±0.9) cm, P<0.001], intraoperative blood loss [(39.1±4.0)ml vs (49.8±4.0) ml, P<0.001], intraoperative fluoroscopy times [(2.8±0.8) vs (3.5±0.8) times, P<0.001], walk time [(92.9±3.0) days vs (102.3±5.1) days, P<0.001], hospital stay [(14.7±1.5) days vs (15.8±1.3) days, P=0.002], hospitalization cost [(1.6±0.1) 10k yuan vs (2.4±0.2) 10k yu-an, P<0.001]. The mean follow-up time lasted for (30.2±7.7) months, and the DCS group resumed full weight-bearing activity significantlyearlier than the LP group [(137.4±5.8) days vs (144.4±3.2) days, P<0.001]. The VAS scores significantly decreased (P<0.05), while the kneeextension-flexion range of motion (ROM) and HSS scores significantly increased in both groups over time (P<0.05), whereas which were notstatistically significant between the two groups at any time points accordingly (P>0.05). As for imaging, the knee flexion angle decreased sig-nificantly after surgery (P<0.05), while the FTA angle and K-L grade remained unchanged in both group (P>0.05). At the matching timepoint, there were no significant differences in knee flexion angle, FTA angle, K-L grade and osteotomy healing between the two groups (P>0.05). [Conclusion] Femoral supracondylar osteotomy combined with DCS or LP fixation for the treatment of knee flexion deformity due topolio sequela is effective and safe. By comparison, the DCS fixation has advantages of short hospital stay, low cost, early ambulation and rela-tively fewer complications over the LP.