Abstract:[Objective] To compare the clinical consequences of unilateral biportal endoscopy (UBE) versus percutaneous endoscopictransforaminal discectomy (PETD) for lumbar disc herniation. [Methods] A retrospective study was done on 67 patients who received endo-scopic discectomy for lumbar disc herniation from February 2019 to September. According to the results of doctor-patient communication,28 patients were treated with UBE, while other 39 cases were with PETD. The perioperative period, follow-up and imaging data of the twogroups were compared. [Results] All patients in both groups were successfully operated on. The UBE group proved significantly less than thePETD group in terms of operative time [(58.1±10.6) min vs (65.5±11.3) min, P=0.009] and intraoperative fluoroscopy times [(3.1±1.1) timesvs (5.2±1.2) times, P<0.001]. However, the former was significantly greater than the latter in terms of incision length [(2.3±0.2) cm vs (1.2±0.2) cm, P<0.001] and the disc volume removed [(3.5±1.1) cm3 vs (2.8±1.1) cm3, P=0.011]. The average follow-up time was (10.5±2.0)months, and there was no significant difference in the time to resume full weight-bearing activities between the two groups (P>0.05). TheVAS and ODI scores in both groups were significantly improved over time (P<0.05). The UBE group was significantly superior to the PETDgroup in terms of the lower back pain VAS [(2.3±0.7) vs (2.7±0.6), P=0.028] and ODI [(27.1±4.9) vs (29.7±5.3), P=0.045] one month postoperatively. As for imaging, the Pfirrmann grade of nerve root compression was significantly improved (P<0.05), and the cross-sectional area ofcanal (CSAC) was significantly increased (P<0.05), while the CSA of the foraminal area remained unchanged in both groups postoperativelycompared with those preoperatively (P>0.05). The UBE group was also better than the PETD group regarding postoperative CSAC [(184.4±40.6) mm2 vs (137.0±28.9) mm2, P<0.001]. [Conclusion] As a new spinal endoscopy technique, unilateral biportal endoscopy has advantag-es of less trauma and full decompression, is conducive to early recovery of patients.