Abstract:[Objective] In three-dimensional models with the bony landmarks consistent with the endoscopic observation, the parame-ters related to L4 outlet nerve root accurately located and safely decompressed was measured for assistance of one-hole split endoscope.[Methods] On the 3D lumbar models of 34 patients with L4/5 unilateral far lateral lumbar disc herniation constructed based on CT, the param-eters in the sagittal plane according to the intersection of the lower margin of the L4 transverse process root with the lateral margin of the isth-mus (ITPI) were measured, including the vertical distance from the ITPI to the upper margin of L4 outlet nerve root (UMNR-L4), the verticaldistance of the lower margin of L4 outlet nerve root (LMNR-L4), the anteroposterior horizontal distance of the posterior margin of L4 outletnerve root (PMNR-L4), the vertical distance of the L4 inferior endplate (IEP-L4), the vertical distance of the L5 upper endplate (UEP-L5), ver-tical distance of the pedicle lower margin of L4 pedicle (LMP-L4), and so on. The data were compared between two genders and two sides.[Results] In term of the lower margin of L4 outlet nerve root projected above the L4/5 intervertebral space, the healthy side was smaller thanthat of the affected side [4/34 (11.8%) vs 18/34 (52.9%)]; while the proportion of healthy side was larger than that of the affected side [30/34(88.2%) vs 12/34 (35.3%)] when projected within the L4/5 intervertebral space. There were no significant differences between two genders andtwo sides in terms of the vertical distance between ITPI and the upper edge of L4 outlet nerve root, the vertical distance between lower edge ofL4 outlet nerve root, the horizontal distance between anterior and posterior edge of L4 outlet nerve root, the vertical distance between lowerend plate of L4, the vertical distance between upper end plate of L5 and the vertical distance between lower edge of L4 pedicle, the left and right horizontal distance of ITPI to the outermost edge of the L4 inferior endplate, the vertical distance of the upper edge of the L4 outlet nerveroot on the sagittal plane, the vertical distance of the lower edge of the L4 outlet nerve root, the vertical distance of the L4 inferior endplate,the vertical distance of the L5 upper endplate located in ITPI, and the left and right horizontal distance of the medial wall of the L4 pedicleand the left and right horizontal distance of the lateral border of the dura (P>0.05). There were no significant correlations among the mea-sured parameters to age and BMI (P>0.05). [Conclusion] As the intersection of the lower margin of the L4 transverse process root with the lat-eral margin of the isthmus was used as the bony landmark, there was no need to explore upward, but only part of the bone is removed outwardand downward to expose and decompress the L4 outlet nerve root safely.