Abstract:[Objective] To investigate the clinical effect of posterior percutaneous large channel endoscopic laminectomy and decom-pression in the treatment of cervical spondylotic radiculopathy. [Methods] A retrospective study was conducted on 32 patients who recervedabovementioned surgical procedure for cervical spondylotic radiculopathy from January 2021 to December 2022. The clinical and imagingdata were evaluated. [Results] All the 32 patients had operation performed successfully without serious complications, with the average oper-ation time of (39.3±5.8) min, average intraoperative blood loss of (15.6±5.4) ml, and followed up for (16.4±3.5) months in a mean. As timeelapsed from the point preoperatively, 3 days after surgery to the last follow-up, the neck and shoulder pain VAS score [(6.7±1.0), (2.2±0.5),(1.3±0.4), P＜0.001], upper limb pain VAS score [(7.4±0.8), (2.3±0.9), (1.3±0.5), P＜0.001] and NDI score [(39.±2.4), (17.7±1.8), (10.7±1.7),P＜0.001] significantly declined, whereas JOA score [(7.3±1.7), (16.4±2.6), (22.63±2.3), P＜0.001] increased significantly. In terms of imag-ing, the responsible segment vertebral canal area [(1.6±0.1) mm2, (1.9±0.1) mm2, (2.0±0.1) mm2, P＜0.001] was significantly increased 3 dayspostoperatively and at the last follow-up compared with that preoperatively, while the intervertebral space height and cervical lordosis angleslightly increased, but without statistically significant differences (P＞0.05). [Conclusion] Posterior percutaneous large-channel endoscopiclaminectomy is a safe and effective surgical method for the treatment of cervical spondylotic radiculopathy.