H型血管在骨-血管偶联稳态维持作用的研究现状△

Research progress on type H vessels in coupling angiogenesis and osteogenesis in bone homeostasis and diseases

摘要:

作为高度血管化的组织，骨骼系统各项功能均由骨内血管系统支持，血管形成与骨形成在时空上存在密切联系。H型血管是一种具有特殊形态结构和功能的骨髓微血管，因其内皮细胞高表达血小板内皮细胞黏附分子-1 （platelet endothelialcell adhesion molecule-1, PECAM-1/CD31） 和内皮黏蛋白（endomucin, Emcn） 而得名。H 型血管是骨-血管偶联稳态维持的关键调控因素，可与骨祖细胞、成骨细胞、破骨细胞前体等相互作用，调节骨形成、骨重塑等骨生理活动，参与如骨质疏松症、骨关节炎等多种骨骼疾病的发生及进展。本文主要对H 型血管在骨-血管偶联稳态维持及骨骼疾病中的最新研究现状进行综述。

Abstract:

As a highly vascularized tissue, the skeletal system can hardly perform its functions without the support from blood vesselsin bone, and angiogenesis is closely associated with osteogenesis spatially and temporally. Recent studies have identified a new type of mi-crovessels in bone marrow with distinct morphological, molecular, and functional characteristics, termed as type H vessels due to the highexpression of platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) and endomucin (Emcn) in the endothelial cells. It was re-vealed that type H vessels were the key regulatory factors for the maintenance of angiogenesis-osteogenesis coupling, regulating physiologi-cal activities such as bone modeling and remodeling through interactions with osteoprogenitors, osteoblasts, and osteoclasts progenitors. Be-sides, type H vessels were also involved in the pathogenesis of various skeletal diseases, such as osteoporosis and osteoarthritis. This reviewaims to summarize the latest research progress on type H vessels and their role in bone disorders.